Research suggests that the combined supplementation of alpha-lipoic acid and CoQ10 may improve energy homeostasis, stress response, and antioxidant defense mechanisms (think beefed up immune system to avoid colds this season). 

What’s all the hub-bub? CoEnzyme Q10 (CoQ10) has an essential function in the electron transport chain in the inner mitochondrial membrane, and is involved with cellular respiration and mitochondrial biogenesis. It is also known as an important antioxidant. Alpha-lipoic acid is synthesized in the mitochondria and plays a role in mitochondrial function. In a recent study, researchers analyzed the effect of combined supplementation of alpha-lipoic acid (ALA) plus CoEnzyme Q10 (CoQ10) on a master switch of energy metabolism and glutathione (GSH) levels. The combination of nutrients significantly increased the levels of PGC1α, a master switch of energy metabolism and mitochondrial biogenesis. The combination also increased gene expression related to stress response, glutathione synthesis and recycling. The increase in glutathione was accompanied by an increase in Nrf2 protein levels. All good stuff, right?  Well, that’s what the scientists say!  So if you need help with figuring out the ins and outs of supplemntation, or just want to know what is best for you, give me a shout out.

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